Rung Five
Supplements
Unclear

Probiotics

probiotic capsules and powders. Fish oil & probiotics.

During treatment: In mice, probiotics weakened the response to immunotherapy; people on immunotherapy should ask first.
Verdict
UnclearThere isn't enough human evidence to say either way.
How sure
Rung 2 · LimitedFew, small or conflicting human studies, or only indirect measures such as blood markers.

The rung shows how sure the science is, not how big the effect is. How to read these ratings

Cancers affected

Melanoma, during immunotherapy

What the evidence shows

In a 2021 study (Science) of people with melanoma on immunotherapy, those who ate enough fiber and didn't take probiotic supplements responded best (82% vs 59%). Probiotics alone weren't significantly linked to survival in people, but in mice they weakened the response to immunotherapy.

What to do

If you're on immunotherapy, ask your care team before taking probiotic supplements. Fiber-rich foods look helpful.

Sources

To take it to your doctor, print this page.

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Related

Every supplement we rated, or follow one cancer step by step: breast cancer, colorectal cancer, lung cancer and prostate cancer.